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Free active neutrophil elastase (NE) is associated with development of bronchiectasis yet the direct mechanism remains unclear. Aim:?Assess physiologically relevant, nanomolar #links# (nM) concentrations of NE on airway epithelial cell (AEC) function and rescue by antiprotease alpha 1-antitrypsin (A1AT). Method:?Non-CF (NuLi & pAECNCF) and CF (CuFi & pAECCF) AECs were used with primary pAECNCF and

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